Quercetin + Nettles 60 Caps

Quercetin + Nettles utilises an innovative form of quercetin known as Quercefit®, which incorporates a phospholipid base for enhanced absorption and bioavailability. Quercetin is traditionally difficult for the body to absorb. When attached to the lecithin-based phytosome, the solubility of quercetin is increased by 20 times, allowing for improved serum levels after supplementation.

It does this by inhibiting the activation of mast cells whilst also stabilising their membranes to inhibit degranulation and histamine release – one study showing that histamine release in nasal tissues may be reduced by between 46% and 99%.4,7 Other anti-inflammatory actions include inhibiting the release of Th-2 derived cytokines and reducing the secretion of antigen-specific IgE antibodies by B-cells. It also suppresses the production of both periostin and periostininduced eosinophil chemoattractants and nitric oxide production in the epithelial tissues of the nose and sinuses.

Furthermore, Quercetin may also reduce the expression of vasoactive intestinal polypeptide (VIP), capillary permeability and platelet aggregation.

It has also been shown to inhibit nuclear factor-kappa B and therefore the subsequent the production and activity of inflammatory cytokines such as prostaglandins, leukotrienes, nitric oxide synthase. It can also inhibit cyclooxygenase-2 enzymes and modify the function of neutrophils.

Preclinical studies have suggested that quercetin also promotes neutrophil chemotaxis and the phagocytic activity of macrophages and Natural Killer cells.